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KMID : 1036820200250020470
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Communication Sciences & Disorders
2020 Volume.25 No. 2 p.470 ~ p.479
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Resting-State Functional Connectivity Mediating for Phonation by the Thalamus in Parkinson’s Disease
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Kim Sun-Woo
Park Yeong-Hun
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Abstract
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Objectives: Phonation impairment is a frequent symptom in patients with Parkinson’s disease (PD). Phonation generally worsens as the disease progresses, causing a progressive loss of communication abilities and increasing isolation from society. Despite our understanding of the sites primarily responsible for phonation in normal subjects (NS), alteration of the functional network in patients with PD still remains unclear. The aim of the present study was to provide evidence of neural systems of phonation, using the resting-state fMRI (rs fMRI) technique, that in comparison to NS, patients with PD exhibited altered functional connectivity associated with the thalamus.
Methods: We acquired rs fMRI, and then analyzed the functional interactions from the seed regions of interest (ventral thalamic nuclei). This study included 14 patients with PD and 10 NS. All participants underwent fMRI scanning with a 3.0-Tesla MRI scanner to obtain T2*-weighted single-shot echo planar imaging sequences.
Results: The results showed that the patients with PD, in the “ON” medication state, exhibited reductions in the right thalamus and both hemispheres of the cortex in the phonation network compared with controls. Specifically, in the PD group, the right thalamus seeds showed strong contralateral connections with the left cortex. In addition, a positive correlation was found between the left precuneus and the both frontal lobules (r>.60) in the PD group.
Conclusion: Using the rs fMRI technique, we provided evidence that the patients with PD exhibited a significantly lower functional connectivity when compared to the NS group in relation to phonation control. Also, our data demonstrated bilateral organization of the rs connectivity in contrast to dominant functional influence of the left hemisphere on correlation organization, and recruitment of the right thalamus within the PD group.
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KEYWORD
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Parkinson’s disease, Resting-state fMRI, Functional connectivity, Thalamus, Phonation
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